What is RepleniCell?


By Jeff Murad, VP of Product Development

Our defining formulation principle at Murad is the Principle of Cellular Water™. This is the idea that as we age or undergo stress or disease, the cells throughout our body lose water through damaged cell membranes. The only way to make skin as healthy and beautiful as possible is to strengthen our cell membranes and ensure that every cell has its optimal concentration of water. Only then is skin truly receptive to targeted treatments for specific skin conditions, such as acne, wrinkles or photodamage. Because of this, hydration (through the use of moisturizers in particular) is an important factor for Murad when our New Product Development team creates formulas.

Traditionally, there are only two methods to hydrate the skin topically. One method is through the use of moisturizers that use humectant ingredients, such as Hyaluronic Acid and Glycerin to attract moisture from the environment. These humectant ingredients are water-soluble.

The second method is through the use of emollient oils that sit on the surface of the skin and prevent water from seeping out—a process known as Transepidermal Water Loss (TEWL). These emollient ingredients are oil-soluble.

As anyone who has made a vinaigrette salad dressing knows oil and water do not mix easily. Because of this, moisturizers are made in two containers. The first contains water and the water-soluble humectant ingredients, while the second contains the oils and oil-soluble emollient ingredients. Only then is an emulsifier added that allows the two sub-formulas to merge into a nice, elegant lotion or cream. Of all of these ingredients and ingredient categories I have listed, there is one that actually does nothing to keep the skin hydrated. Surprisingly, this non-hydrating ingredient (that is central to any good moisturizer) is the water itself. Without the presence of special molecules, water is unable to pass through the cell membranes in our bodies (including our skin cells). So the water in your moisturizer—the one that is the first or second ingredient (meaning it is at least 50% of your formula)—is doing nothing except solubilizing (dissolving) the humectant ingredients in the formula.


The question the New Product Development team at Murad was faced with was: how do we get that inactive 50% of the formula to become an active hydrator for the skin? To find the answer, we looked at skin biology. The cells in our bodies are actually able to move water around, but only through very specific methods. Deep within the surface of the skin, cells use special water channels known as aquaporins to move water in and out in a single file line. Closer to the surface, water molecules pair up with chaperones, known as osmolytes, that allow them to pass through cell membranes as needed. Looking at this process for inspiration, researchers at Murad discovered a unique blend of osmolytes and aquaporin stimulators we call RepleniCell®, that “activates” water to help transport and lock it into the surface layers of the skin.

Now, before we begin to manufacture any Murad moisturizer, we start with a tank loaded with water that has been pretreated with this RepleniCell® cocktail, rather than the standard water all other moisturizers begin with. Once all of the mixing is complete, we are left with a product that is not 50% active, but rather has the ability to be a full-performance hydrator for all of our skin.


 By Jeff Murad, VP of Product Development. Dr. Murad’s son and VP of New Product Development Jeff Murad oversees product formulation and testing.



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New products focus – Blackhead & Pore Clearing Duo

Sure, there are lots of products on the market that claim to clear your pores. And sure, we have tried most of them. But that’s pretty much all they do. Murad takes pore management one step further with Blackhead and Pore Clearing Duo —a two-step treatment to get your pores unclogged and keep them clear. The first step is an extracting mask that effectively unclogs and draws impurities from the skin. The second step is a pore sealant that helps prevent the formation of future blackheads.



  • Blackheads
  • Enlarged or Clogged Pores
  • T-zone Shine

Everyone has experienced the condition of clogged pores in their lifetime. Blackhead and Pore Clearing Duo has become a top 20 selling Murad product in Sephora U.S. Customers are becoming increasingly focused on the issue of pore size as their skin ages, so Blackhead and Pore Clearing Duo is an excellent upsell to any skincare regimen.

Use 2-3 times per week as needed. Blackhead Remover: Apply generously to areas prone to blackheads, leave on for up to 10 minutes. Add warm water and gently massage into skin to exfoliate. Rinse thoroughly and pat dry. Follow with Pore refining Sealer.
Pore Refining Sealer: immediately following use of Blackhead remover, apply a thin layer to entire face. To help prevent future blackheads, apply a second layer 12 hours after initial treatment. Follow with a Murad Step 3 moisturizer after each application.






  • Volcanic Mineral Clay and Shikakai Extract detoxify, drawing out dirt, cellular debris and excess oil, to purify pores and help prevent clogging
  • Oxidation reversal Complex prevents sebum oxidation and helps to reverse oxidation that has already occurred
  • Pomegranate Seed Oil helps protect cells from damaging free radicals and tightens enlarged pores


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Contrôler – Matifier – Hydrater

Trouver une crème qui ne soit pas grasse mais qui malgré tout, vous offre suffisament d’hydration semble difficile à trouver. Pourtant Docteur Murad a mis au point une formule qui va apporter une hydratation maximale à votre peau et une matité à toute épreuve.

A votre réveil utilisez le nettoyant de votre choix, hydratant ou tonique afin que votre peau soit debarassée de toutes impuritées et prête à recevoir les soins qui vont suivre.




Appliquer une petite noisette de votre Matifiant Régulateur de Sébum FPS 15, sur l’ensemble de votre visage. Sa texture oncteuse mais non grasse, gorgera votre peau d’actifs afin de lisser votre peau, et les extraits de saule permettront de controller les excès de sébum.


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We have some exciting news to share! The NEW Acne Starter Kit.

kitOur reconfigured Acne Starter Kit will restore your skin’s health, clarity and appearance—now more than ever before! As always, our goal at Murad is to offer our customers the very best products, with the most innovative, effective ingredients, so you can have beautiful skin.


This kit features Acne Clearing Solution, providing even better clearing than the Acne Complex Kit. 96% of users saw clearer skin in 72 hours (in a Murad-sponsored study, individual results will vary), with less risk of dryness, redness and peeling. The Acne Starter Kit also includes Murad’s bestselling Clarifying Cleanser, Clarifying Mask and Oil-Control Mattifier SPF 15.

No matter what your skin type, age or acne concern, Murad has a specially designed three-step regimen and acne product kit to meet your needs.

Clearing acne doesn’t need to be complicated. Three simple steps done twice a day, combined with a healthy lifestyle, can help you get clear, radiant skin.

This powerful gel cleanser combats acne and skin breakouts. The rich lather strips away pore-clogging grime, oil and irritants as it helps treat and prevent acne breakouts with time-released medication that remains active for hours, even after rinsing.

This maximum strength cleansing gel cleanser combats acne and skin breakouts. Encapsulated Salicylic Acid continually releases acne treatment for hours even after rinsing. Silver Citrate provides powerful antibacterial protection to inhibit blemish formation.

Massage small amount over dampened face and neck. Rinse with warm water and pat dry.

2Acne Clearing Solution: This powerful formula swiftly treats breakouts, blemishes, and redness while restoring skin clarity and treating the underlying causes of acne to prevent future breakouts.

This non-comedogenic treatment clears breakouts while managing acne-related symptoms to help achieve healthy, blemish-free skin.

Massage evenly over clean face, neck and chest. Follow with a Murad Step 3 moisturizer.

Clarifying Mask:This weekly treatment for acne-prone skin featuring a natural clay-based formula calms skin, reduces irritation and minimizes breakouts. Helps absorbs pore clogging dirt and oil as it draws out impurities.

Apply an even layer over clean skin. Leave on for 10 minutes. Rinse thoroughly with warm water and pat dry. For optimal results, use at least once a week and follow with recommended Murad Step 2 treatment and Step 3 moisturizer.

3A shine-reducing moisturizer that creates an immediate matte surface and controls oil for up to 8 hours. Protects blemish-prone skin and supports natural oil balance throughout the day.

Oil-Control Mattifier SPF 15 is a clinically proven formula that reduces shine on contact and controls oil for up to 8 hours while effectively reducing breakouts. Oil-Control Complex® helps regulate oil production while preserving moisture to provide a long-lasting matte finish.

Apply liberally to face, neck and chest.

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Murad Skincare Haul a review by Alexis Mae

Alexis Mea is a professional hair stylist and beauty blogger. This is her review of the following products:
“I’ve dealt with acne and uneven texture creating a uncomfortable feeling with my skin”

  • Renewing Cleansing Oil
    Step #1 Cleanse: Formula abundant in natural botanical oils, gently cleanses and renews the skin while maintaining skin’s natural moisture barrier.
  • Clarifying Cleanser
    Step #1 Cleanse: This maximum strength cleansing gel cleanser combats acne and skin breakouts. 92% of users experienced a reduction in acne breakouts in just 3 days*. Encapsulated Salicylic Acid continually releases acne treatment for hours even after rinsing


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